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Stamets Stack Protocol and Other Microdose Stacks

Stamets stack protocol
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Paul Stamets is a mycologist and author, who has been studying the medicinal properties of mushrooms for over four decades. In recent years, he has developed a protocol for microdosing various species of fungi, which he believes can have a wide range of benefits for mental and physical health. The Stamets Stack protocol consists of Lion’s mane, psilocybin, and niacin combined together in order to improve brain health and cognitive function.

The Stamets Microdosing Stack 

One of Paul Stamets’s pending patent applications is the Stamets Stack Protocol. It is a procedure and set of elements that are considered to improve cognition and neuroregeneration in people.

Stamets Stack is believed to be a neurodegeneration and cognition-enhancing stack that contains lion’s mane mushroom, psilocybin, and niacin. According to Stamets, these compounds are believed to synergize in such a way that our body’s ability to create new neurons and repair existing neurological damage is significantly improved.

While psilocybin and Lion’s mane have neurodegenerative ability, niacin on the other hand functions as an anti-abuse component, and it helps in the distribution of psilocybin across the blood-brain barrier, and migrate through the peripheral and central nervous system, according to Stamets.

The Stamets Stack Protocol is a composition believed to improve and prepare neurological function synergistically.

Lion’s Mane

Lion’s mane mushrooms (Hericium erinaceus) are a type of edible fungi that have been used for centuries in traditional Chinese medicine. In recent years, they have gained popularity among mushroom enthusiasts and natural health enthusiasts alike, due to their unique appearance and potential health benefits.

For example, one study found that lion’s mane mushrooms contain compounds called hericystin and erinacine, which may have neuroprotective effects. These compounds are thought to support the growth and repair of nerve cells in the brain, which can help to improve cognitive function and memory. As stated by Paul Stamets, Lions mane is a key component in his stack, as these improvements synergize with the benefits of psilocybin mushrooms.

Another study found that lion’s mane mushrooms may also have anti-inflammatory and antioxidant properties. This can help to protect the brain from damage caused by free radicals, which are molecules that can harm cells and tissues in the body.


Psilocybin is a naturally occurring psychedelic compound found in certain species of mushrooms. Recently it started gaining recognition for its potential neuroprotective effects.

Recent studies have suggested that psilocybin may be able to protect the brain from damage caused by conditions such as stroke and traumatic brain injury. This is because psilocybin is believed to help support the growth and survival of neurons.

While more research is needed to fully understand the potential therapeutic effects of psilocybin, the current evidence suggests that it may have significant potential as a neuroprotective agent and as a treatment for mental health conditions such as depression.


Niacin, also known as vitamin B3, is an essential nutrient that plays a vital role in many of the body’s processes. It is found in a wide range of foods, including meat, fish, eggs, and vegetables, and is also available as a dietary supplement.

Niacin is involved in many important functions in the body, including energy production, DNA repair, and the metabolism of fats and carbohydrates. It is also necessary for the production of sex and stress-related hormones and plays a key role in the functioning of the nervous system.

In addition to its various physiological functions, niacin has also been shown to have some potential health benefits. For example, it has been shown to help lower levels of cholesterol and triglycerides in the blood, which can reduce the risk of heart disease.

Niacin has also been studied for its potential role in improving cognitive function and treating Alzheimer’s disease. Some research suggests that niacin supplements may help to improve memory and other cognitive abilities in older adults.

Stamets Stack Protocol Dosage

According to a lecture at the Psychedelic Science Conference 2017, Paul Stamets has a specific stacking formula based on an individual weighing 163 lbs.

Lion’s Mane –  5 to 20 g.

Psilocybin – 0.1 to 1 g (a microdose).

Niacin – 100 to 200 mg.

What are the Benefits? 

According to Paul Stamets, Lion’s Mane, psilocybin, and niacin offer a synergistic effect on neurological growth and cognitive function. Paul Stamets Protocol is believed to deliver the following benefits:

  • Promotion of neurogenesis;
  • Reduced depression and anxiety;
  • Improved motor skills;
  • Improved cognition and memory;
  • Stabilized mood;
  • Enhanced creativity;
  • Improved vision and hearing;
  • Relieve from PTSD symptoms;
  • Reduced neuropathy;
  • Increased ability to empathize and socialize;
  • Enhance self-awareness.

Important Notes 

Stamets Stack Protocol should be done in the following manner, four days on followed by three days off to avoid building a tolerance to psilocybin. Finish a four-week cycle and then take a two to four weeks break before starting the protocol again.

Avoid the no-flush niacin type as it will not work with the stacks. In order to reduce the flushing effects of niacin, slowly increase the dose over time.

Obtain your psilocybin mushrooms from a trusted source, and always check the local laws.

Other Microdose Stacks 

Stamet Stack Protocol is not the only one out there, there are other microdose stacks as well. Some people stack other psychedelics like ayahuasca or LSD with medicinal mushrooms and additional vitamins such as B12. There are also reports of stacking psychedelics with raw cacao. Cacao is not a psychedelic drug, but it does have a psychoactive effect as a mood enhancer, it is also filled with antioxidants, rich in minerals, and contains theobromine that may act like a mild stimulant.

Learn More: Complete Guide to Microdosing Psilocybin Mushrooms

stamets stack protocal

Stacking LSD is another option people who microdose like to implement into their routine. LSD is a powerful psychedelic substance that is known for its ability to alter consciousness and induce altered states of perception. It is often used in microdosing stacks to enhance creativity, boost mood, and improve focus and concentration

Microdosing Ayahuasca is not that popular, but it still allegedly offers similar benefits as other psychedelics. It is a psychedelic substance that is derived from the Banisteriopsis caapi vine, which is native to the Amazon rainforest. It is known for its ability to induce powerful spiritual experiences and is often used in microdosing stacks to promote spiritual growth and personal development.


Stamets stacks are combinations of multiple different substances that are used to enhance the potential effects and to address specific health concerns. The use of psychedelic stacks, also known as polypharmacology, is becoming increasingly popular among those who use psychedelics for therapeutic purposes.

It is believed that Stamets Stack Protocol improves neurogenesis in the brain and even acts as a neuroprotective agent. There are other stacks with similar benefits, although Stamets Stack is the most commonly used microdosing stack today.


🍄 The Stamets Microdose Stack is a combination of mushrooms (Lion’s Mane, psilocybin) and niacin known for their cognitive-enhancing properties.

🧠 The stack is believed to improve brain health, cognitive function, and neuroregeneration.

🦁 Lion’s Mane mushrooms contain compounds that support the growth and repair of nerve cells, potentially improving cognitive function and memory.

🍄 Psilocybin, a psychedelic compound found in certain mushrooms, may protect the brain from damage and have potential therapeutic effects for mental health conditions.

💊 Niacin (vitamin B3) plays a role in energy production, DNA repair, and nervous system functioning. It may help lower cholesterol, improve cognitive function, and treat Alzheimer’s disease.

💡 The recommended dosage for the Stamets Stack Protocol: Lion’s Mane (5-20g), Psilocybin (0.1-1g), Niacin (100-200mg).

🌱 The benefits of the Stamets Stack Protocol may include promotion of neurogenesis, reduced depression and anxiety, improved cognition and memory, enhanced creativity, and more.

⚠️ Important notes: Follow the four-day-on, three-day-off cycle to avoid tolerance to psilocybin. Use the appropriate type of niacin to reduce flushing effects. Obtain mushrooms from a trusted source and comply with local laws.

🍄 There are other microdose stacks, such as those involving psychedelics like ayahuasca or LSD, as well as stacking with cacao.

✅ The use of psychedelic stacks, including the Stamets Stack, is gaining popularity for therapeutic purposes and enhancing the effects of psychedelics.


This website does not promote or endorse the cultivation or use of psilocybin mushrooms. Psilocybin can be illegal and pose health risks. Always check your local laws and consult a medical professional before considering psilocybin use. Content is designed for adults aged 18 and over.

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The Ultimate Magic Mushroom Strain Guide

Unlock the secrets of the magical world of mushrooms with 'The Ultimate Magic Mushroom Strain Guide'. Learn all about the different psilocybin mushroom strains nature has to offer.



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